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Buy Esketamine nasal spray here at our online pharmacy. “Of nearly 300 million people who suffer from major depressive disorder worldwide, about 1/3 of them don’t respond to currently available treatments. This represents a major unmet public health need,” said Mathai Mammen, MD, Ph.D., Global Head, Janssen Research & Development, LLC, in a statement.
Esketamine nasal spray DNA was supported by data from 5 phase. 3 studies in patients with treatment-resistant depression. Patients with treatment-resistant depression are those whose depression has not responded to 2 or more treatments. Buy Esketamine at our online drugstore
Short Term Study
In a short-term study, patients were randomized to flexible doses Esketamine nasal spray (56mg or 84mg twice weekly). Plus a newly initiated oral antidepressant or placebo nasal spray plus a newly initiated oral antidepressant. Patients in the Esketamine nasal spray arm experienced a significant clinical improvement in depressive symptoms. As measured by the change from baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) total score. Least Squares Mean Difference Standard Error from placebo nasal spray plus a newly initiated oral antidepressant.
The most commonly reported treatment-related adverse effects (>10%) in the Esketamine treatment group were metallic taste, nausea, vertigo, dizziness, headache, drowsiness, dissociation, blurred vision, paranesthesia, and anxiety. While in the placebo group, metallic taste and headache were reported. Buy Ketamine nasal spray at Pillzphamra
Long Term Study
A longer-term study of 705 patients with treatment-resistant depression also randomized participants to 56 or 84 mg Esketamine nasal spray plus oral antidepressant or placebo plus an antidepressant. The regimen consisted of intermittent dosing over 16 weeks.
Among stable patients in remission, 24 (26.7%) of patients in the Esketamine treatment arm relapsed, compared to 39 (45.3%) of patients in the placebo arm. Buy Esketamine
Also, this drug was proven to target critical aspects of glutamate-mediated synaptic plasticity. Thereby bringing about rapid and sustained improvement in people with treatment-resistant depression, ” said Husseini K. Manji, MD, Global Head, Neuroscience Therapeutic Area, Janssen Research & Development, LLC.
The FDA previously granted ketamine nasal spray a Breakthrough Therapy Designation for use in treatment-resistant depression. And also for a second indication, major depressive disorder with imminent risk for suicide.
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